TPA is also known as a clot buster..it breaks up any blood clots and thins the blood. Given during a short period of time after a stroke TPA can save lives. If given to someone not having a stroke it would thin the blood. Thinning the blood does increase the risk of bleeding anywhere in the body including the brain. The effects of TPA are not permanent and will wear off.

Nothing. Well, there may be an increased risk of bleeding from sites like ulcers, haemorrhoids or open wounds. But that is all transient, and would resolve soon.